Establishing Serum Reference Ranges for Antihypertensive Drugs

Background: Therapeutic drug monitoring (TDM) involves the measurement of serum concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used evaluate antihypertensive response. However, approximately 50% hypertensive patients treated with lifestyle changes drugs fail achieve control. Serum concentration could be useful select optimal in adjusted doses identify nonadherence. Implementation TDM clinical routine for depends on established reference ranges. Methods: Commonly were identified based prescription data. The authors performed a review authoritative literature reported calculated expected from previously pharmacokinetic parameters commonly prescribed daily doses. Finally, samples undergoing treatment measured. Results: ranges 24 frequently results 3 approaches. Conclusions: measurements, interpreted light ranges, together other data, may help nonadherent tailor individual when deviant responses appear line concept personalized medicine.